Synjardy Empagliflozin Metformin 5/850 mg Tablets

Description

Synjardy empagliflozin metformin 5 mg/850 mg is a prescription combination tablet for adults with type 2 diabetes when diet, physical activity and the current treatment plan do not provide adequate control. Each film-coated tablet contains empagliflozin 5 mg and metformin hydrochloride 850 mg. The Turkish pack shown on this page contains 60 tablets and is manufactured for Boehringer Ingelheim.

This guide explains the medicine, its usual administration, monitoring and the warning signs that need urgent care. It does not replace the dose written by your doctor or the leaflet supplied with your pack.

Synjardy empagliflozin metformin: quick facts

What Synjardy empagliflozin metformin does

The two ingredients lower glucose through different mechanisms. Empagliflozin blocks SGLT2 in the kidneys, so more glucose leaves the body in urine. Metformin reduces glucose production by the liver and improves the body’s response to insulin. Used together, they can improve glycaemic control when the combination is suitable for the individual patient.

The medicine is not insulin and is not intended for type 1 diabetes. Its suitability depends on kidney function, current medicines, hydration, acute illness and the patient’s risk factors. The approved role may also differ by country, so the prescriber and the local leaflet remain decisive.

How to take Synjardy empagliflozin metformin safely

Take Synjardy empagliflozin metformin exactly as prescribed. Immediate-release Synjardy is commonly taken twice daily with meals. Taking it with food can reduce metformin-related stomach upset. Swallow the tablet with water and do not change the strength or frequency without medical advice.

• Take doses at consistent times with meals.
• If you miss a dose, follow the patient leaflet; never double the next dose.
• Maintain normal fluid intake unless your clinician has restricted fluids.
• Tell every treating clinician that you use empagliflozin and metformin.
• Do not use another metformin- or empagliflozin-containing product unless the prescriber has reviewed the total dose.

7 vital safety checks before and during treatment

1. Kidney function

Kidney function must be checked before treatment and monitored periodically. It affects whether Synjardy empagliflozin metformin is suitable and which strength can be used. Severe renal impairment can increase metformin accumulation and lactic-acidosis risk, while dehydration may cause a sudden decline in kidney function.

2. Lactic acidosis

Lactic acidosis is rare but life-threatening. Seek emergency help for severe weakness, persistent vomiting, abdominal pain, muscle cramps, difficult or rapid breathing, unusual sleepiness, feeling cold or a slow heartbeat. Risk rises with severe kidney problems, dehydration, heavy alcohol intake, uncontrolled diabetes, serious infection, reduced oxygen supply or prolonged fasting.

3. Diabetic ketoacidosis

Empagliflozin can rarely cause diabetic ketoacidosis even when blood glucose is not very high. Stop taking the medicine and obtain urgent medical care if nausea, vomiting, abdominal pain, excessive thirst, rapid deep breathing, confusion, unusual tiredness or sweet-smelling breath develops. Illness, surgery, fasting, marked reduction in food intake, dehydration and sudden insulin reduction can raise this risk.

4. Surgery, fasting and acute illness

A doctor may temporarily stop Synjardy empagliflozin metformin before major surgery or during prolonged fasting, vomiting, diarrhoea, fever, severe infection or another acute serious illness. Do not make the interruption plan alone; ask the treating team when to stop and when it is safe to restart.

5. Iodinated contrast scans

Tell radiology staff and the prescriber before an X-ray or CT procedure using iodinated contrast. Metformin-containing treatment may need to be paused and restarted only after kidney function has been reassessed, according to the clinician’s instructions.

6. Dehydration, urinary and genital infections

Because empagliflozin increases urinary glucose, thirst, increased urination, genital fungal infection and urinary infection may occur. Contact a clinician for burning urine, fever, back pain, genital irritation or unusual discharge. Severe pain, redness or swelling around the genitals or perineum with fever or malaise needs urgent assessment because rare Fournier’s gangrene has been reported.

7. Other diabetes medicines and vitamin B12

Low blood sugar is more likely when Synjardy empagliflozin metformin is combined with insulin or a sulfonylurea; those doses may need review. Long-term metformin can reduce vitamin B12, so tingling, anaemia, extreme tiredness or a sore red tongue should be discussed with a clinician.

Common and important side effects

Common effects may include nausea, diarrhoea, abdominal discomfort, reduced appetite, taste change, genital fungal infection, urinary symptoms, thirst and increased urination. These are not the only possible effects. Persistent symptoms, recurrent infections or signs of volume depletion such as dizziness on standing require medical advice.

Stop the medicine and seek urgent care for suspected lactic acidosis or ketoacidosis, severe allergic reaction, inability to keep fluids down, marked dehydration, severe urinary infection or painful swelling of the genital/perineal area. Report unexpected effects through the local pharmacovigilance system.

Who needs an individual medical review?

Before using Synjardy empagliflozin metformin, discuss pregnancy or breastfeeding, kidney or liver disease, heart or circulation problems, recurrent urinary or genital infections, pancreatitis history, heavy alcohol use, low-carbohydrate or ketogenic diets, planned surgery and every prescription, over-the-counter medicine or supplement. Older adults and people taking diuretics or blood-pressure medicines may be more vulnerable to volume depletion.

Turkish pack identity and storage

The official images show the front and back of a Turkish Synjardy 5 mg/850 mg pack containing 60 film-coated tablets. The 5/850 tablet is described in approved information as yellowish-white, oval and biconvex, with identifying markings. Check the strength, tablet count, batch and expiry before use. Keep tablets in the original package, away from children, moisture and excessive heat, and follow the storage statement printed on the Turkish carton and leaflet.

Synjardy empagliflozin metformin FAQ

Is it used for type 1 diabetes?

No. Synjardy empagliflozin metformin is not indicated for type 1 diabetes and the ketoacidosis risk is particularly important.

Can I take it without food?

It is generally taken with meals to improve gastrointestinal tolerability. Follow the exact directions on your prescription.

Should I stop it before an operation?

Often a temporary interruption is required, but timing depends on the procedure and clinical condition. Contact the surgical or diabetes team in advance.

Does normal glucose rule out ketoacidosis?

No. SGLT2-associated ketoacidosis can occur with glucose below the levels usually expected in diabetic ketoacidosis. Symptoms require urgent assessment.

Where can I verify the official information?

See the European Medicines Agency Synjardy overview and the current Synjardy Summary of Product Characteristics. You can also browse the No Style Like English store for related health products.

Medical disclaimer: This page is educational and is not a diagnosis, prescription or substitute for professional care. Use only under medical supervision and follow the leaflet supplied with your own pack.