Diane 35 is a combined hormonal tablet<\/strong> containing cyproterone acetate 2 mg and ethinylestradiol 35 micrograms<\/strong>. Made by Bayer, it is used in women of reproductive age<\/strong> to treat skin conditions driven by male hormones (androgens) \u2014 chiefly moderate-to-severe acne related to androgen sensitivity and\/or hirsutism<\/strong> (excess unwanted hair). Because it also acts as a hormonal contraceptive<\/strong>, it provides birth control while treating these conditions.<\/p>\n Diane 35 is a prescription-only medicine. It is not intended as a routine contraceptive<\/strong>: it should be used specifically for its approved androgen-related skin indications, and for acne only after topical treatments and oral antibiotics have not worked. It carries an important risk of blood clots, so it must be prescribed and monitored by a doctor.<\/p>\n Diane 35 contains two hormones: cyproterone acetate<\/strong>, an anti-androgen and progestogen, and ethinylestradiol<\/strong>, a synthetic oestrogen.<\/p>\n Cyproterone acetate blocks androgen receptors<\/strong> and reduces the body’s own androgen production, lowering the effect of male hormones on the skin’s oil glands and hair follicles \u2014 which improves acne, oily skin, and excess hair. Ethinylestradiol<\/strong> regulates the menstrual cycle, raises sex-hormone-binding globulin (further lowering free androgens), and, with cyproterone’s progestogenic effect, provides contraceptive cover<\/strong> by suppressing ovulation.<\/p>\n Diane 35 is indicated for the treatment of moderate to severe acne related to androgen sensitivity (with or without seborrhoea) and\/or hirsutism<\/strong> in women of reproductive age. For acne, it should be used only when alternative treatments such as topical therapy or oral antibiotics have failed. It is often prescribed to manage the androgenic skin symptoms of polycystic ovary syndrome (PCOS)<\/strong>, though PCOS itself is not a formal licensed indication. It should not be used solely as a contraceptive.<\/p>\n Take one tablet daily for 21 days<\/strong>, starting on day 1 of the menstrual cycle, followed by a 7-day tablet-free interval<\/strong> during which a withdrawal bleed occurs; the next pack starts after those 7 days. Tablets should be taken in the order shown on the pack, at about the same time each day<\/strong>. Treatment usually continues for several cycles until the skin condition resolves, and is often stopped 3\u20134 cycles after symptoms clear. Follow your doctor’s instructions on starting and duration.<\/p>\n Swallow each tablet whole with a little water<\/strong>, at the same time daily, following the arrows on the blister pack. Take it consistently to maintain both the skin benefit and contraceptive protection. Do not combine Diane 35 with another hormonal contraceptive, as this raises oestrogen exposure and clot risk. If you vomit or have severe diarrhoea within a few hours of a tablet, absorption may be reduced \u2014 follow the leaflet’s missed-tablet advice.<\/p>\n If you are less than 12 hours late<\/strong>, take the missed tablet at once and continue as normal; contraceptive protection is maintained. If you are more than 12 hours late<\/strong>, protection may be reduced \u2014 take the most recent missed tablet now, continue the pack, and use additional (barrier) contraception for 7 days, following the detailed instructions in the package leaflet. If tablets are missed in the first week and intercourse occurred, seek advice.<\/p>\n Overdose has not been associated with serious harm but may cause nausea, vomiting, and, in young girls, some vaginal bleeding<\/strong>. There is no specific antidote; treatment is symptomatic and supportive. Contact your doctor or pharmacist if a large number of tablets have been taken, especially by a child.<\/p>\n Store Diane 35 in its original packaging at room temperature, below 25\u201330\u00b0C<\/strong> as stated on the pack, away from moisture and out of direct sunlight. Keep it out of the reach and sight of children. Do not use tablets after the expiry date, and dispose of unused medicine responsibly according to local guidance rather than in household waste.<\/p>\n Diane 35 is contraindicated in women with a current or past venous or arterial thromboembolism<\/strong> (DVT, pulmonary embolism, heart attack, stroke) or high risk of these, severe or multiple risk factors<\/strong> for clots, migraine with aura, serious liver disease or liver tumours<\/strong>, known or suspected sex-hormone-dependent cancers<\/strong> (such as breast cancer), pregnancy or breastfeeding<\/strong>, undiagnosed vaginal bleeding, and hypersensitivity to any ingredient. It must not be used together with another hormonal contraceptive.<\/p>\n The most important risk is venous and arterial thromboembolism<\/strong> (blood clots); the VTE risk is estimated to be higher than with some standard combined contraceptives and is greatest in the first months of use and after restarting. Risk rises with age, smoking, obesity, prolonged immobility, and a personal or family history of clots<\/strong>. Other precautions include effects on blood pressure, liver function, gallbladder, and glucose<\/strong>, and a possible small increase in breast cancer risk. Doctors should discuss clot risk factors and review treatment regularly.<\/p>\n Common effects, often settling over the first few cycles, include headache, nausea, breast tenderness, mood changes, weight change, and breakthrough bleeding or spotting<\/strong>. Serious effects requiring urgent medical attention<\/strong> include signs of a blood clot \u2014 painful swollen leg, sudden chest pain or breathlessness, coughing blood, sudden severe headache, weakness or numbness on one side, or sudden vision loss \u2014 as well as yellowing of the skin (liver problems) and signs of a severe allergic reaction.<\/p>\n Several medicines can reduce Diane 35’s effectiveness<\/strong> and cause breakthrough bleeding or contraceptive failure, including enzyme-inducing drugs<\/strong> such as certain anticonvulsants (carbamazepine, phenytoin, barbiturates, topiramate), rifampicin<\/strong>, some HIV medicines, and the herbal remedy St John’s wort<\/strong>. Some antibiotics and other drugs may also interact. Extra (barrier) contraception may be needed during and after such treatments. Tell your doctor about all medicines and supplements you use.<\/p>\n Before starting, the doctor reviews personal and family medical history and checks blood pressure<\/strong>, assessing clot and cardiovascular risk factors. A first follow-up is recommended about 3 months<\/strong> after starting, then periodically. Ongoing monitoring includes blood pressure and a review of any new risk factors or symptoms. Women should be re-assessed against the approved indication at each scheduled visit, and treatment stopped once the skin condition has adequately resolved.<\/p>\n To reduce clot risk, avoid smoking<\/strong>, maintain a healthy weight, stay active, and move regularly during long journeys or periods of immobility. Learn the warning signs of a blood clot so you can act quickly. A balanced skincare routine can complement treatment of acne. Keep all review appointments, report new symptoms promptly, and tell any treating doctor that you are taking a combined hormonal product.<\/p>\n Skin improvement is gradual: acne and hirsutism typically improve over 3 to 6 cycles<\/strong> of consistent use, with many women showing clear improvement in facial acne after about six cycles. Contraceptive protection, by contrast, begins from correct first use. Because cyproterone has a long half-life, effects build over the first weeks. Treatment is usually continued for a few cycles after the condition clears, then stopped, as directed by your doctor.<\/p>\n As a combined hormonal product, Diane 35 interacts with enzyme-inducing drugs (reducing its effect) and can influence conditions sensitive to hormones or clotting. Conditions such as hypertension, diabetes, migraine, liver or gallbladder disease, and a history of clots<\/strong> strongly affect whether it can be used. Because it is also a contraceptive, it must never be combined with another hormonal contraceptive. All conditions and medicines should be reviewed by the prescriber.<\/p>\n Seek emergency care immediately<\/strong> for signs of a blood clot: a painful, swollen, or warm leg; sudden breathlessness or chest pain; coughing up blood; sudden severe headache or migraine unlike usual; weakness, numbness, or drooping on one side; or sudden loss of vision or speech. Also contact your doctor for yellowing of the skin or eyes, a new breast lump, severe mood changes, or if you might be pregnant.<\/p>\n Diane 35 is for women of reproductive age<\/strong> with the approved skin conditions; it is not for men, children before menarche, or after the menopause<\/strong>. It is contraindicated in pregnancy and breastfeeding<\/strong>. Risk of clots increases with age and smoking, and it is generally avoided in women over 35 who smoke. It should be used with particular caution, or avoided, in those with cardiovascular, liver, or clotting risk factors, and reassessed regularly.<\/p>\n Diane 35 should be avoided by women with a history of blood clots or high clot risk, migraine with aura, serious liver disease, hormone-dependent cancers, undiagnosed vaginal bleeding, or during pregnancy or breastfeeding, and by anyone hypersensitive to its ingredients. It should not be used purely for contraception, nor combined with another hormonal contraceptive, and heavy smokers, especially over 35, should generally avoid it.<\/p>\n What is Diane 35 used for?<\/strong> Diane 35 treats moderate-to-severe androgen-related acne and hirsutism in women of reproductive age, and also acts as a hormonal contraceptive.<\/p>\n Is Diane 35 a contraceptive?<\/strong> It provides contraception, but it should be used for its approved skin indications rather than solely for birth control, and never alongside another hormonal contraceptive.<\/p>\n How is it taken?<\/strong> One tablet daily for 21 days, followed by a 7-day tablet-free week, then a new pack, taken at the same time each day.<\/p>\n What is the main risk?<\/strong> The main risk is venous and arterial blood clots (VTE\/ATE); risk factors include smoking, age, obesity, and immobility.<\/p>\n How long until acne improves?<\/strong> Skin usually improves over about 3 to 6 cycles of consistent use.<\/p>\n This page was medically reviewed by Dr. Abdallah Fouad, Clinical Nutrition Specialist<\/strong> with over 25 years of experience. The content is provided for educational purposes to help patients understand how Diane 35 (cyproterone acetate\/ethinylestradiol) is used, its benefits, and its risks. It does not replace the personalized advice of your treating physician or pharmacist.<\/p>\n Diane 35 is a prescription-only medicine that must be prescribed and monitored by a qualified physician, particularly because of its blood-clot risk. This content is for general information only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, changing, or stopping any medication.<\/p>\n","protected":false},"excerpt":{"rendered":" Diane 35 (cyproterone acetate 2 mg \/ ethinylestradiol 35 mcg) is a combined hormonal tablet for moderate-to-severe androgen-related acne and hirsutism in women of reproductive age, also providing contraception. Prescription only; carries an important risk of blood clots (VTE\/ATE).<\/p>\n","protected":false},"featured_media":11407142,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[39177],"product_cat":[42013],"product_tag":[38758],"class_list":["post-11397195","product","type-product","status-publish","has-post-thumbnail","product_brand-bayer-en","product_cat-fertility-pregnancy","product_tag-hormonal-balance","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product\/11397195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/comments?post=11397195"}],"version-history":[{"count":5,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product\/11397195\/revisions"}],"predecessor-version":[{"id":11404366,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product\/11397195\/revisions\/11404366"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/media\/11407142"}],"wp:attachment":[{"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/media?parent=11397195"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product_brand?post=11397195"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product_cat?post=11397195"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/nostylelike.net\/en\/wp-json\/wp\/v2\/product_tag?post=11397195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Active Ingredients & Mechanism of Action<\/h2>\n
Approved Indications<\/h2>\n
Dosage & Administration<\/h2>\n
How to Take Diane 35<\/h2>\n
Missed Dose<\/h2>\n
Overdose<\/h2>\n
Storage Conditions<\/h2>\n
Contraindications<\/h2>\n
Warnings & Precautions<\/h2>\n
Common & Serious Side Effects<\/h2>\n
Drug Interactions<\/h2>\n
Required Tests & Monitoring<\/h2>\n
Diet & Lifestyle Support<\/h2>\n
Expected Timeline for Improvement<\/h2>\n
Effect on Other Medications & Conditions<\/h2>\n
When to See a Doctor<\/h2>\n
Use in Special Populations<\/h2>\n
Who Should Avoid Diane 35?<\/h2>\n
Frequently Asked Questions<\/h2>\n
Medical Review & Author Note<\/h2>\n
Medical Disclaimer<\/h2>\n