Product Specifications

• Name: Nexavar 200 mg Sorafenib Tablets

• Brand: Bayer

• Strength: 200 mg

• Quantity: 60 tablets

• Form: Film-coated tablets

• Appearance: White/blue carton box containing blister strips

• Expiry: Printed on the pack (usually 2–3 years from manufacturing)

• Country of Origin: Germany

• Product Code: NEX-200-BAYER-60

Detailed Overview

Nexavar 200 mg is a multi-kinase inhibitor that blocks cancer cell proliferation and prevents tumor angiogenesis. It is indicated for:

• Hepatocellular carcinoma (HCC) not amenable to surgery.

• Renal cell carcinoma (RCC) advanced or metastatic cases.

• Differentiated thyroid carcinoma (DTC) refractory to radioactive iodine.

⚠️ Note: Nexavar is a prescription-only drug and should never be self-administered.

Mechanism of Action

Sorafenib targets multiple intracellular and surface kinases such as RAF kinases, VEGFR, and PDGFR, leading to:

• Inhibition of new blood vessel formation feeding the tumor.

• Suppression of tumor growth signaling.

Warnings & Precautions

• Contraindicated in patients with hypersensitivity to Sorafenib.

• Not recommended during pregnancy or breastfeeding.

• Caution in patients with cardiac disease, uncontrolled hypertension, or liver dysfunction.

Side Effects

• Common: Diarrhea, rash, loss of appetite, hand-foot syndrome, hypertension.

• Serious: Abnormal bleeding, chest pain, jaundice, irregular heartbeat.

Drug Interactions

Nexavar may interact with:

• Strong CYP3A4 inducers/inhibitors (e.g., antifungals, antivirals, anticonvulsants).

• Anticoagulants such as Warfarin.

• Herbal supplements like St. John’s Wort.
  Always disclose all medications to your healthcare provider.

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FAQs

1. What is Nexavar used for?
   For advanced liver, kidney, and thyroid cancers under medical supervision.

2. Is it a cure?
   No, it helps control cancer progression but does not cure.

3. How is it taken?
   Usually twice daily, as prescribed by your doctor.

4. Can it be taken during pregnancy?
   No, it is unsafe during pregnancy and breastfeeding.

5. What if I miss a dose?
   Take the next dose at the scheduled time; do not double up.

6. Does it cause hair loss?
   It may cause thinning hair or hair loss in some patients.

7. Does it affect blood pressure?
   Yes, it may cause hypertension; monitoring is required.

8. Are routine tests needed?
   Yes, regular blood work for liver, kidney, and thyroid function.

9. Are there alternatives?
   Yes, such as Stivarga, Lenvima, or Keytruda depending on your condition.

10. Can I take herbal supplements?
    Not without consulting your doctor; some may reduce effectiveness.

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