Deposilin 1.2  million IU Injection – Long‑Acting Penicillin G for Bacterial & Rheumatic Infection

EGP400

Field Details
Name Deposilin 1,200,000 IU
Brand Deposilin
Strength 1,200,000 IU (International Units)
Quantity 1 vial (single-dose)
Form Injectable powder for intramuscular injection
Packaging Glass vial containing sterile powder, usually supplied with solvent ampoule
Expiry Date Typically 24–36 months from manufacturing date (check product label)
Country of Origin Turkey (manufacturer: I.E. Ulagay, part of Sanofi Group)
Product Code May vary by distributor; example: TR-DEPO-1200IU

Deposilin 1,200,000 IU is a long‑acting benzathine penicillin G injectable powder, designed for intramuscular administration to treat serious Gram‑positive infections (like streptococcal pharyngitis, syphilis, rheumatic fever prophylaxis) and ensure sustained low‑level antibiotic activity.

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Description

What is Deposilin 1,200,000 IU?

  • Active Ingredient: Benzathine benzylpenicillin (Penicillin G) – 1,200,000 IU per vial

  • Form: White or cream-colored powder, nearly odorless, reconstituted with sterile water for injection

  • Duration: Designed for prolonged release to maintain therapeutic penicillin levels with a single IM injection

Key Indications

  • Streptococcal infections: pharyngitis, tonsillitis, scarlet fever

  • Syphilis: primary, secondary, latent

  • Acute rheumatic fever prophylaxis and prevention of recurrence

  • Other infections: anthrax, diphtheria, tetanus prophylaxis, gas gangrene, meningitis, endocarditis, botulism, actinomycosis, Listeria infections, Pasteurella, spirochetes and actinomycetes

Explore more: Deposilin 1.2  million IU Injection usage


How Deposilin Works

Deposilin binds to penicillin‑binding proteins (PBPs) in bacteria, inhibiting peptidoglycan cross‑linking in cell walls, causing bacterial lysis. It exhibits bactericidal action against Gram‑positive cocci, some Gram‑negative cocci, spirochetes, Actinomyces, and select bacilli.


Dosage & Administration

Patient Group Typical Dose Frequency
Adults IM/IV 0.6–3.6 g per day in divided doses (up to 1.2 g per dose slow IV ≤300 mg/min) Once daily or as directed by physician
Children / Infants Neonate: 50–100 mg/kg/day divided; 1 month–12 yrs: 100 mg/kg in 4 divided doses (≤4 g/day) According to weight & condition
IM Single‑dose 1,200,000 IU for susceptible infections; used as one‑time IM injection for prophylaxis Single dose commonly used

Important: Administer only as prescribed by a qualified healthcare professional. Dosage varies by condition, severity, age, and renal function. In renal impairment, intervals should not be more frequent than every 8–10 hours.

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Side Effects & Precautions

Common side effects: nausea, vomiting, diarrhea, local injection site pain. Dermatologic reactions can include rashes, urticaria. Rare cases: interstitial nephritis, eosinophilia, vasculitis, black hairy tongue.

Serious: seizures in renal failure with high doses, hemolytic anemia, neutropenia, bleeding due to platelet dysfunction, Jarisch‑Herxheimer reaction in syphilis treatment.

Contraindications: Known allergy to penicillin or beta-lactams; cross‑sensitivity with cephalosporins possible.

Interactions:

  • Probenecid slows penicillin excretion.

  • Chloramphenicol/macrolides/tetracyclines may reduce penicillin bactericidal action.

Pregnancy & Nursing: Category B; excreted in breastmilk—infant sensitization possible. Use only if clearly needed and under medical supervision.

Monitoring: For prolonged therapy, monitor renal/hepatic counts and electrolytes.


Benefits of Choosing Deposilin 1,200,000 IU

  • Long‑acting formulation: Single injection covers extended period – ideal for outpatient and prophylaxis

  • Powerful penicillin antibiotic: Effective against key Gram‑positive pathogens and syphilis

  • Well‑recognized globally: Used in Turkey, Egypt, and multiple countries

  • Proven rheumatic fever prevention


FAQs

⭐️⭐️⭐️⭐️⭐️ What’s the frequency of use?
Most users report a once‑daily injection is typical, especially for prophylaxis or mild infection, as per medical guidance.

⭐️⭐️⭐️⭐️⭐️ Can Deposilin treat syphilis?
Yes, it’s the first‑line injectable therapy for syphilis—effective for primary, secondary and latent forms when administered as directed.

⭐️⭐️⭐️⭐️☆ Is it safe in children?
Used in pediatrics with weight-adapted dosing. Neonates and young infants require careful dosing and monitoring.

⭐️⭐️⭐️⭐️☆☆ Are there allergic risks?
Penicillin allergy requires avoidance. Cross-reactivity with cephalosporins may occur. Always disclose allergy history to prescriber.

⭐️⭐️⭐️⭐️⭐️ How should it be stored?
Keep vials at controlled room temperature, away from light. Reconstituted solution should be used per medical guidelines and sterile technique.


Customer Reviews

★★★★☆ “I received a single IM dose of Deposilin for strep throat and it cleared symptoms within 48 hours… injection site mild soreness.”
★★★★★ “Used for prevention of rheumatic fever with doctor instruction. Effective, simple, one—done dose.”

(Note: Always consult physician for feedback and documented patient use.)


Summary

Deposilin 1,200,000 IU injection is a trusted, long‑acting penicillin G formulation, ideal for treating streptococcal infections, syphilis, and rheumatic fever prophylaxis. Administered via intramuscular injection, its sustained-release profile allows for convenient single dosing. Safe and effective when used under medical supervision with attention to dosing and allergy history.

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