Description
Croma PolyPhil Injectable Polynucleotides 1 x 2 ml – A Skin Booster for Skin Quality, Not a Filler: A Complete 22-Section Guide
Quick answer:
Croma PolyPhil by Croma-Pharma, Austria, is an injectable polynucleotide (PN-HPT) gel, 40 mg in 2 ml (20 mg/ml). It is a skin booster, not a volumising filler: it is used to improve skin quality, including firmness, elasticity, hydration and fine crepey lines of the face, neck, decollete and hands. It does not add volume or lift. The box holds 1 prefilled 2 ml syringe with 30G 1/2 inch (13 mm) needles. A qualified doctor gives it as intradermal micro-injections, usually in a series of sessions. It is never self-injected, and results vary.
Urgent safety warning: vascular occlusion
Any facial injection carries a rare risk of product entering a blood vessel. Pale or white skin, a mottled or dusky patch, severe or increasing pain, or any change in vision during or after a session is an emergency: tell the injecting doctor immediately or go to an emergency department. Very rarely this can cause skin necrosis, vision loss or stroke. Note that hyaluronidase acts on hyaluronic acid products only, so it does not dissolve polynucleotides.
Key Facts About Croma PolyPhil
| Name | Croma PolyPhil Injectable Polynucleotides 1 x 2 ml |
| Manufacturer | Croma (Croma-Pharma, Austria), PolyPhil line |
| Active component | Polynucleotides (PN-HPT) 40 mg per 2 ml (20 mg/ml) |
| Product type | Skin-quality (biorevitalising) injectable; not a volumising filler |
| Pack | 1 prefilled syringe x 2 ml sterile injectable gel |
| Needles | 30G 1/2 inch (13 mm) |
| How it is given | Intradermal micro-injections by a qualified doctor |
| Course | A series of sessions set by the doctor, often 2 to 4 sessions a few weeks apart |
| Lidocaine | Not listed in the composition |
| Expiry | Printed on the pack |
Short description: A polynucleotide skin booster that doctors use in a course of sessions to improve the firmness, elasticity and hydration of tired, thin or crepey skin, and that complements fillers rather than replacing them.
On this page
- Introduction
- What is it?
- How polynucleotides work
- What it can help with
- Illustrative situations
- Who may benefit
- Who should avoid it
- How is it used?
- Planning your course
- Results timeline
- Common mistakes
- Myths and facts
- Side effects
- Interactions
- Warnings
- Assessment before treatment
- Pairing with fillers and skincare
- How it compares
- When to contact the doctor
- NSL expert tip
- FAQ
- Conclusion
Introduction to Croma PolyPhil
Not every ageing concern is about missing volume. Many people notice that their skin itself has changed: it looks dull, feels thinner, creases like tissue paper on the neck or under the eyes, and no longer bounces back. A filler adds volume in one spot, but it does not change the quality of the skin around it. Croma PolyPhil is designed for that second problem.
This page explains what Croma PolyPhil is, why it is a skin booster rather than a filler, how a course of sessions works, and what results are realistic. If you are comparing it with volumising products, our guide to types of dermal fillers explains the differences. Everything here is educational; your doctor decides whether and how to use it.
What Is Croma PolyPhil?
Croma PolyPhil is a sterile injectable gel containing polynucleotides (PN-HPT), 40 mg in 2 ml, which is 20 mg/ml. It is made by Croma-Pharma in Austria as part of the PolyPhil line. Each box contains one prefilled 2 ml syringe for single use, supplied with 30G 1/2 inch (13 mm) needles.
Croma PolyPhil is a skin-quality, or biorevitalising, injectable. It is not a volumising filler and is not used to add volume, fill hollows or lift the face. Like the fillers in this range, it is a professional medical device sold for clinics and doctors, not a product for home use.
How the Polynucleotides in Croma PolyPhil Work
Polynucleotides are chains of nucleotides, the building blocks of DNA. In aesthetic medicine they are used as skin boosters: injected in tiny amounts into the dermis, they are intended to support the skin’s own repair and hydration processes, which is why the effect is described as biorevitalising.
Because the aim is to improve the skin gradually rather than to fill a space, Croma PolyPhil is given as many small intradermal micro-injections across an area, usually in a series of sessions. Research on polynucleotides is growing but still more limited than for hyaluronic acid fillers, so expectations should stay realistic.
What Croma PolyPhil Can Help With
- Croma PolyPhil is used to improve skin firmness and elasticity.
- May improve hydration and the overall look of tired, dull skin.
- Used for fine crepey lines on the face, neck, decollete and hands.
- Used by doctors in protocols for acne scars and stretch marks.
- Used to prepare the skin before other procedures.
- Pairs with fillers: it works on skin quality while fillers work on volume.
It does not add volume, lift sagging tissue or replace a filler.
Croma PolyPhil in Practice: Illustrative Situations
These are simplified examples of clinical reasoning, not promises.
A woman in her forties with crepey skin on the neck: there is no volume to replace, but the skin creases easily. A doctor may suggest a course of a skin booster such as Croma PolyPhil to work on skin quality.
A man with old, shallow acne scars and dull skin: some doctors include polynucleotides in a scar protocol, often alongside other treatments chosen for the scar type.
A patient who already had cheek filler but still feels the skin looks tired: the volume is restored, but texture and glow are not. Croma PolyPhil may complement the filler rather than more filler being added.
Who May Benefit From Croma PolyPhil
- Adults whose main concern is skin quality: thinness, dullness, loss of elasticity or fine crepey lines.
- People wanting to treat the neck, decollete or back of the hands as well as the face.
- Patients in a doctor’s protocol for acne scars or stretch marks.
- People who already have fillers and want to improve the skin over them.
- Only after a consultation with a qualified doctor.
Who Should Avoid Croma PolyPhil
- A history of severe allergies or anaphylaxis.
- Allergy to any ingredient of the product, or to any anaesthetic the doctor plans to use.
- Active skin infection, inflammation or acne at the treatment area.
- Bleeding disorders.
- Pregnancy and breastfeeding: not studied, so avoid.
- Under 18, or below the age stated on the label.
- Autoimmune disease or a history of keloids: the doctor must assess first.
- A recent laser or peel at the area.
- Anyone whose main goal is volume or lifting: a different product is needed.
How Is Croma PolyPhil Used?
Croma PolyPhil is given only by a qualified, trained doctor in a clinic. It is never self-injected, and the syringe is not meant for home use. A course usually follows these steps:
- Consultation: the doctor reviews your history, medicines and allergies, examines the skin and explains whether a skin booster suits your concern.
- Numbing: the doctor may apply a numbing cream before the micro-injections, as they judge appropriate.
- Treatment by the doctor: the doctor gives intradermal micro-injections and decides the amount and pattern for you.
- Series of sessions: treatment is often 2 to 4 sessions a few weeks apart, as decided by the doctor.
- Aftercare: for about 24 to 48 hours avoid makeup, heavy exercise, saunas, alcohol and pressing or massaging the area unless the doctor says otherwise.
Planning Your Croma PolyPhil Course
Small bumps, redness and pinpoint bruises from micro-injections usually settle within days, so plan sessions away from important events. Because a full course can span several weeks, decide on the timing with the doctor at the first consultation. Avoid starting while you have active acne, a cold sore or a recent peel at the area, and ask the doctor about supplements that increase bruising. Never stop prescribed blood thinners yourself.
Croma PolyPhil Results Timeline
- Right after a session: small raised bumps and redness at the injection points; this is not the result.
- First days: bumps, redness and any bruising usually settle.
- Over the course: changes in skin quality, if they happen, build up gradually across the series of sessions rather than appearing at once.
- After the course: the doctor reviews the skin and may suggest maintenance. The pack does not state a fixed duration.
Results vary and are not guaranteed. For how long volumising fillers usually last, see how long fillers last.
Common Mistakes
- Expecting Croma PolyPhil to fill hollows, lift cheeks or plump lips; it is not a volumising filler.
- Judging the result after one session instead of after the full course.
- Buying a syringe to inject at home or by a non-doctor.
- Assuming it can be dissolved like hyaluronic acid filler; hyaluronidase acts on hyaluronic acid products only.
- Skipping sun protection, which undoes skin-quality work.
Myths and Facts
Myth: Croma PolyPhil is just another filler. Fact: it is a polynucleotide skin booster for skin quality, not volume.
Myth: one session is enough. Fact: it is usually given in a series of sessions decided by the doctor.
Myth: skin boosters reverse ageing. Fact: they may improve the look of skin quality; they do not cure ageing, and results vary.
Side Effects of Croma PolyPhil
Common effects are temporary and usually settle within days to about 1 to 2 weeks:
- Redness and small bumps at the injection points.
- Swelling and tenderness.
- Pinpoint bruising.
- Itching.
Rare but serious effects include injection into a blood vessel, infection, delayed nodules or granulomas, and allergic reactions. Read our article on side effects of dermal fillers for the general picture with facial injectables.
Interactions
- Blood thinners and antiplatelet medicines raise the chance of bruising from the many small injections. Tell the doctor; do not stop them without the prescribing doctor.
- Aspirin and NSAIDs such as ibuprofen may increase bruising.
- Supplements such as omega-3 and vitamin E may also increase bruising.
- Numbing products: lidocaine is not listed in the Croma PolyPhil composition, but if the doctor uses a numbing cream or local anaesthetic, mention any allergy to lidocaine or other local anaesthetics.
Warnings
- Vascular occlusion: blanching, mottling, severe pain or vision changes are an emergency. Contact the injector or go to an emergency department at once.
- Hyaluronidase acts on hyaluronic acid products only; it does not dissolve polynucleotides.
- Professional use only: given by a qualified doctor in a clinic, never self-injected.
- Single use: never re-use or share a syringe. Store as on the label; do not freeze.
- No guaranteed result.
Assessment Before Croma PolyPhil
Routine blood tests are not usually needed for healthy adults. The doctor’s assessment matters more: skin condition and any active acne or infection, allergies, medicines and supplements, bleeding tendency, autoimmune conditions, keloid history, and previous treatments in the area. Photos in the same light before the first session and after the course make it easier to judge any change.
Pairing Croma PolyPhil With Fillers and Skincare
- Volumising hyaluronic acid fillers, when the doctor finds volume loss as well as poor skin quality.
- Collagen-stimulating treatments in some plans; see our Sculptra guide.
- Daily broad-spectrum sunscreen.
- A simple routine with a gentle cleanser and moisturiser; ask before using strong acids or retinoids around sessions.
Croma PolyPhil Compared With Fillers
| Product | Type | Concentration | Lidocaine | Typical use |
|---|---|---|---|---|
| Juvederm Voluma | Cross-linked HA filler (VYCROSS) for deep volume | 20 mg/ml | Yes, 0.3% | Cheek and midface volume, chin and jawline projection, temple hollows |
| Juvederm Ultra 4 | Cross-linked HA filler (HYLACROSS) | 24 mg/ml | Yes, 0.3% | Deep folds such as nasolabial and marionette lines, lip volume |
| Teosyal RHA 2 | Resilient HA filler (RHA) for moving areas | 23 mg/ml | Yes, 0.3% | Moderate dynamic lines around the mouth, smoker lines, nasolabial folds, subtle lip enhancement |
| Aliaxin SV | Highly cross-linked HA filler of non-animal origin | 25 mg/ml | No | Structural volume for cheekbones, midface and chin |
| Croma PolyPhil | Polynucleotide skin booster, not a volumising filler | 20 mg/ml (40 mg per 2 ml) | Not listed in the composition | Skin firmness, elasticity, hydration and fine crepey lines of face, neck, decollete and hands |
The other four products in this table are hyaluronic acid fillers that add or support volume. Croma PolyPhil is the only skin booster: it works on skin quality and can complement any of them.
When to Contact the Doctor
- Immediately: pale, white or mottled skin, severe or increasing pain, or vision changes.
- Increasing redness, heat, pus or fever.
- Swelling of the face, lips or throat, or difficulty breathing: emergency.
- Bumps that persist, harden or appear weeks later.
- Redness or swelling that does not settle after about two weeks.
NSL Expert Tip
From the No Style Like pharmacy team: think of Croma PolyPhil as care for the canvas, and fillers as changes to the shape. If your doctor finds both volume loss and tired skin, the plan may include both, but they are different products with different jobs. Ask how many sessions are planned, take photos in the same light before the first and after the last, and judge the course as a whole.
Croma PolyPhil FAQ
Is Croma PolyPhil a filler?
No. It is a polynucleotide skin booster for skin quality; it does not add volume or lift.
How many sessions are needed?
The doctor decides; it is often 2 to 4 sessions a few weeks apart.
Which areas is it used on?
Face, neck, decollete and hands, and in doctors’ protocols for acne scars and stretch marks.
Does it contain lidocaine?
Lidocaine is not listed in its composition; the doctor decides on any numbing.
Can it be dissolved with hyaluronidase?
No. Hyaluronidase acts on hyaluronic acid products only.
What is in the box?
One prefilled 2 ml syringe with 30G 1/2 inch (13 mm) needles.
What is the expiry date?
The expiry date is printed on the pack.
Croma PolyPhil: Conclusion
Croma PolyPhil is a 20 mg/ml polynucleotide skin booster in a 2 ml syringe, used by doctors in a course of sessions to improve skin firmness, elasticity, hydration and fine crepey lines. It is not a volumising filler, it is injected only by a qualified doctor, results vary, and blanching, severe pain or vision change after any session is an emergency. Doctors and clinics can order it from No Style Like Pharmacy with delivery across Egypt.
Reviewed by the No Style Like Pharmacy content team. This information is for educational purposes only.
This is a prescription medical device for professional use; follow the instructions for use and your doctor’s advice. This content does not replace medical advice. Learn more at FDA – Dermal filler dos and don’ts.
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