Capecitabine 500 mg (Capecitajet) 120 Tablets For the treatment of colon and breast cancer

ntroduction to Capecitabine 500 mg (Capecitajet)

Capecitabine, marketed under the brand name Capecitajet, is an oral chemotherapy medication used to treat several types of cancer, including breast cancer, colorectal cancer, and gastric cancer. Unlike intravenous chemotherapy, Capecitabine is taken orally in tablet form, making it a convenient choice for many patients.

It belongs to the antimetabolite class of chemotherapy drugs. After ingestion, Capecitabine is converted inside the body into its active form, 5-fluorouracil (5-FU), which interferes with DNA synthesis in cancer cells, preventing their growth and multiplication.

Composition and Strength

• Active ingredient: Capecitabine

• Strength: 500 mg per tablet

• Form: Film-coated tablets

• Packaging: Boxes containing 120 tablets

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Indications: What is Capecitabine 500 mg Used For?

Capecitabine is prescribed for the treatment of:

1. Colorectal cancer (colon and rectum cancer) – as a first-line therapy or after surgery.

2. Breast cancer – particularly when other treatments such as paclitaxel or anthracyclines have failed.

3. Gastric cancer – in combination with other chemotherapy drugs.

4. Pancreatic and other solid tumors – in some cases under oncologist recommendation.

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How Capecitabine Works

Once ingested, Capecitabine undergoes enzymatic conversion inside the liver and tumor tissues, turning into 5-FU. This substance interferes with DNA synthesis and repair inside rapidly dividing cancer cells, leading to their death.

The unique advantage is that 5-FU is produced more selectively in tumor tissues compared to healthy cells, helping reduce toxicity.

Dosage and Administration

• Typical dosage: The doctor calculates the dose based on body surface area (BSA).

• Common regimen: Twice daily (morning and evening), after meals.

• Cycle: Usually taken for 14 consecutive days followed by 7 days of rest.

• Tablets must be swallowed whole with water, not crushed or chewed.

⚠️ Never self-prescribe. Capecitabine is a powerful chemotherapy drug that should only be used under medical supervision.

Side Effects of Capecitabine 500 mg

Like all chemotherapy medications, Capecitabine can cause side effects. Some are mild and manageable, while others may require medical attention.

Common side effects:

• Diarrhea

• Nausea and vomiting

• Loss of appetite

• Fatigue

• Mouth sores (stomatitis)

• Hand-foot syndrome (redness, swelling, or pain in palms and soles)

• Rash or skin irritation

Serious side effects:

• Severe diarrhea or dehydration

• Chest pain or irregular heartbeat

• Bleeding, bruising easily

• Severe allergic reaction

• Liver or kidney dysfunction

Warnings and Precautions

1. Do not use if allergic to Capecitabine or fluorouracil.

2. Not recommended during pregnancy or breastfeeding.

3. Patients with severe kidney or liver impairment should avoid use.

4. Inform your doctor if you are taking blood thinners (e.g., warfarin).

5. Regular blood tests are required during treatment.

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Interactions with Other Medications

Capecitabine may interact with:

• Anticoagulants (Warfarin) → increased risk of bleeding

• Phenytoin → elevated blood levels

• Leucovorin → enhanced side effects of Capecitabine

• Allopurinol → reduced effectiveness

Always inform your oncologist about any medications or supplements you are taking.

Storage Instructions

• Store below 30°C in a dry place.

• Keep away from children.

• Do not use after the expiry date printed on the package.

Price of Capecitabine 500 mg (Capecitajet)

• Pack of 120 tablets (500 mg each): Price varies depending on country.

• In Egypt, average retail price is around 2200 – 2500 EGP.

• International prices may vary depending on manufacturer and insurance coverage.

Patient Tips for Better Outcomes

• Stay hydrated to manage side effects.

• Maintain a balanced diet to strengthen immunity.

• Inform your doctor immediately if you experience severe diarrhea or bleeding.

• Use supportive treatments prescribed by your doctor to minimize side effects.

Conclusion

Capecitabine (Capecitajet) is an effective oral chemotherapy option for patients with breast, colorectal, and gastric cancers. Its convenience of oral administration makes it preferable for many patients, but due to its potency and potential side effects, it must always be taken under strict oncologist supervision.

Frequently Asked Questions (FAQ)

What is Capecitabine used for?

It is used to treat breast, colorectal, and stomach cancers.

Is Capecitabine 500 mg chemotherapy?

Yes, it is an oral chemotherapy drug that works similarly to IV chemotherapy.

How should I take Capecitabine?

Take it twice daily after meals, exactly as prescribed.

Can Capecitabine cure cancer?

It does not guarantee a cure but helps control and reduce cancer growth.

What should I do if I miss a dose?

Skip it and continue with the next dose. Never double the dose.

Is it safe during pregnancy?

No, it should not be used during pregnancy or breastfeeding.

How long does treatment last?

It depends on the cancer type and patient’s response, usually several cycles.

What foods should I avoid while taking Capecitabine?

No specific restrictions, but avoid alcohol and maintain a healthy diet.

Does Capecitabine 500 mg cause hair loss?

Unlike many chemotherapy drugs, it usually causes minimal or no hair loss.

Can Capecitabine be combined with other drugs?

Yes, often used with other chemotherapy agents depending on the treatment plan.

User Reviews ⭐⭐⭐⭐⭐

⭐️⭐️⭐️⭐️⭐️ – “Very effective in controlling my colon cancer. Side effects were manageable with doctor’s guidance.”

⭐️⭐️⭐️⭐️ – “Good alternative to IV chemo. Easier to take, but I experienced fatigue.”

⭐️⭐️⭐️⭐️⭐️ – “Helped me during breast cancer treatment. Hand-foot syndrome was tough, but treatment worked.”

⭐️⭐️⭐️ – “Strong drug, caused diarrhea, but results were worth it.”

⭐️⭐️⭐️⭐️⭐️ – “Life-saving medication. Grateful for oral chemotherapy option.”

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